Literature summary for 2.3.1.291 extracted from

Wegner, M.S.; Wanger, R.A.; Oertel, S.; Brachtendorf, S.; Hartmann, D.; Schiffmann, S.; Marschalek, R.; Schreiber, Y.; Ferreiros, N.; Geisslinger, G.; Groesch, S.
Ceramide synthases CerS4 and CerS5 are upregulated by 17beta-estradiol and GPER1 via AP-1 in human breast cancer cells (2014), Biochem. Pharmacol., 92, 577-589 .

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Application

Application	Comment	Organism
medicine	in human breast cancer tissue, a significant increase in CerS4 and CerS6 mRNA is observed in estrogen receptor positive cancer tissue. The activities of CerS4 and CerS5 promoter constructs increase after estradiol treatment in MCF-7 cells. Estradiol and GPER1 mediate their effects on CerS4 and Cers5 promoter by activating AP-1, most likely through dimerization of c-Jun and c-Fos	Homo sapiens
medicine	in human breast cancer tissue, a significant increase in CerS4 and CerS6 mRNA isobserved in estrogen receptor positive cancer tissue. The activities of CerS4 and CerS5 promoter constructs increase after estradiol treatment in MCF-7 cells. Estradiol and GPER1 mediate their effects on CerS4 and Cers5 promoter by activating AP-1, most likely through dimerization of c-Jun and c-Fos	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N5B7	isoform CerS5	-
Homo sapiens	Q9HA82	isoform CerS4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CerS4	-	Homo sapiens
CerS5	-	Homo sapiens

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Release 2023.1 (January 2023)